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Sharma, Mohit Kumar
- Potential Of Marine Biomolecules As The Promising Life-Style Drugs
Authors
Source
International Journal of Innovative Research and Development, Vol 2, No 9 (2013), Pagination:Abstract
The lifestyle drugs are the modern pharmaceutical innovations. They are Pharmacoeconomics assets of the 21st century. A new term QOL (quality oriented life improving drugs) has augmented their prospective potential. Marine biomolecules offered novel chemical entities (NCEs) of polypharmacophoric bioactions for improving the style and quality of life. The antidepressive, cosmeceutical, and aphrodisiacal potentials of marine novel chemical entities were explored in this study.
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- Chemopharmacological Correlation Of Antidepressant Structures For Drug-Design
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International Journal of Innovative Research and Development, Vol 2, No 9 (2013), Pagination:Abstract
The chemopharmacological correlation is based on the principles of chemical pharmacology. Possibly it may be new attempt to design antidepressant of therapeutical specificity, by correlating the antidepressive structures of natural origin and synthetic through molecular association or simplification. Serotonim and Norepinepherine selected as the structural standards. They have Indolyl, catechol, aliphatic chain of two carbons and the protonated tertiary nitrogen at the physiological pH are topographical entities for the receptor affinity and intrinsic efficacy of pharmacodynamic value, thus induce the conformational change for the biological response.The structural diveregence of non-SSRIs was rationalized by agumentation, receptor diversification and topographical selectivity. Mitrazepin, Neurontin, Pregabalin and Tramadol have special structural values. Receptor specificity and critical moieties of agonist, partial agonist and antagonist studied for finding out their role in correlation. The overall chemopharmacological correlation has empirically defined the partial components of antidepressive receptor specificity as indolyl, tertiary nitrogen, catechol and aryls. The concepts of isosterism and bioisosterism were not considered. The topographical entities of antidepressants belonging to natural and synthetic, termed as critical for utilizing them for the molecular design.
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- Molecular Pharmacology Of Antidepressive Terrestrial Natural Products (TNPs)
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International Journal of Innovative Research and Development, Vol 2, No 6 (2013), Pagination:Abstract
Our new approach explored the phytopharmacotherapeutical significance of antidepressive TNPs through theoretical studies based on the antidepressant chemical structures.
Keywords
Antidepressive, 5-HT (Serotonin), natural products, pharmacophoric, terrestrial.Full Text
- CMOS Analog Multipliers: Low Power Design Strategies and the Impact of Threshold Voltage Variations
Authors
1 Department of Electronics and Communication Engineering, Manipal University Jaipur, Rajasthan., IN
Source
Journal of Mines, Metals and Fuels, Vol 71, No 4 (2023), Pagination: 502-507Abstract
Due to process variations in key MOSFET parameters like channel length, width, threshold voltage (Vth ) etc. the output of analog circuits is affected to a large extent. In this work, our aim is to examine the yield of a typical CMOS analog multiplier designed at 65 nm technology node due to Vth variations and figure out the variation in key parameters by using Gaussian distribution - Monte Carlo model. We have considered a typical Quad multiplier configuration to examine the variability in the multiplier output under 2% and 5% variation in threshold voltage of the 65 nm bulk BSIM model. Using the case of Gaussian distribution - Monte Carlo simulation, the standard deviation in the multiplier output is found to be 1.4 mV for both 2% and 5% variations. A good yield prediction with variation of 2% and 5% in V th is possible at 65 nm technology node.Keywords
Cmos Analog Multipliers, Analog Circuits, Process Variations, Reliability, Monte Carlo Models.
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